I will praise thee;
for I am fearfully and wonderfully made:
Psalm 139:14
"....a molecular machine that works like a mousetrap. How cool is that? No kidding, here's how the authors of a paper in the Proceedings of the National Academy of Sciences describe serpin antithrombin III (for short, ATIII):Here the cellular folding pathway of the serpin antithrombin III (ATIII), which inhibits proteases
involved in the coagulation cascade, was determined. ATIII uses a large conformational movement in a mousetrap-like mechanism to bind and distort its target protease, resulting in protease inhibition. This work establishes that folding to an active, cocked state requires early stabilization of the C-terminal region, which is the last sequence translated, explaining how the serpin or mousetrap is set.
Here we find a mousetrap, a molecular machine, and the blood clotting cascade brought together in a single irreducibly complex protein. And proteins, we all know, are coded by complex specified information -- another hallmark of intelligent design -- in the genome.
Be glad you have ATIII in your bloodstream. It's an anticoagulant, helping prevent thrombosis and pulmonary embolism. It plays a very important role in regulating normal blood coagulation. As a serpin (serine protease inhibitor), its job is to prevent runaway clotting by deactivating a certain protease called thrombin." EN&V