3 Things happen according to the book of Daniel when the Time of the End begins:
1) Sanctuary Cleansed
2) Knowledge Increase
3) King of the South pushes against the King of the North
But thou, O Daniel, shut up the words, and seal the book, even to the time of
the end: many shall run to and fro, and knowledge shall be increased. Daniel 12:4
There are 2 views as to this knowledge increasing part:
1) Human Knowledge such as technology, etc.
2) Spiritual Knowledge as to the understanding of the Prophecies
Both types have happened rapidly since the end of the 2300 days/years which begin the Time of the End according to the book of Daniel. -1844
As for human/technical knowledge-look at the rapid increase since the mid-1800's... The technology has led us to a global village (internet, facebook, 24-hour cable news, etc). Now the whole wide world is connected and if the mark of the beast is implemented, now all will see and hear-and decide for themselves which side they are on.