Thank you for making me so wonderfully complex!
Your workmanship is marvelous...
Your workmanship is marvelous...
Psalm 139:14
"Life runs on ribosomes.
Every cell across the globe requires
ribosomes to convert genetic data into the vital proteins required for
the organism’s operation, and, subsequently, for the production of more
ribosomes. 
However, scientists still lack a clear understanding of how
these essential nanomachines are assembled.
Now,
new high-resolution images of the large ribosomal subunit are shedding
light on how arguably nature’s most fundamental molecule coalesces in
human cells.
The findings, published in Science, bring us one step closer to a complete picture of ribosome assembly. Klinge and colleagues focused on the human large ribosomal subunit
(60S). The team already knew, from studies in yeast, that the large
subunit’s formation involves two precursors (a 5S rRNA and 32S pre-rRNA)
snapping together, but “we wanted to know all of the events that need
to happen for this to occur,” says Arnaud Vanden Broeck, a postdoctoral
researcher in Klinge’s lab.
“We wanted to explain how the large subunit
is assembled and processed in human cells.”
Klinge and Vanden Broeck are content to marvel at the substantial leap
forward. “It’s not guesswork anymore,” Klinge says. “We can now see, in
detail, what’s going on when the large subunit assembles. It’s humbling
to realize we’re finally able to see what makes ribosomes and drives
protein formation in all of our own cells.”
SciTechDaily
