Creation Moment 4/15/2014 - Cellular Trash Cans

Your cellular trash cans go through a series

of checks before compacting the trash

"The 26S proteasome is a 2.5 MDa molecular machine that executes

the degradation of substrates of the ubiquitin–proteasome pathway. The molecular architecture of the 26S proteasome was recently established by cryo-EM approaches.
Our analysis reveals the existence of three major conformations: in addition to the previously described ATP-hydrolyzing (ATP_h) and ATP-γS conformations, an intermediate state has been found. Its AAA-ATPase module adopts essentially the same topology that is observed in the ATP_h conformation, whereas the lid is more similar to the ATP-γS bound state. Based on the conformational ensemble of the 26S proteasome in solution, we propose a mechanistic model for substrate recognition, commitment, deubiquitylation, and translocation into the core particle." PNAS


Complexity = DESIGN, hence a DESIGNER

 I will praise thee;

for I am fearfully and wonderfully made:

marvellous are thy works;

Psalm 139:14