And the Spirit & the bride say, come.... Reveaaltion 22:17

And the Spirit & the bride say, come.... Reveaaltion 22:17
And the Spirit & the bride say, come...Revelation 22:17 - May We One Day Bow Down In The DUST At HIS FEET ...... {click on blog TITLE at top to refresh page}---QUESTION: ...when the Son of man cometh, shall he find faith on the earth? LUKE 18:8

Sunday, January 13, 2013

Creation Moment 1/14/2013 - Protein Coding Variants

And hath made of one blood all nations of men for to dwell on all the face of the earth,
and hath determined the times before appointed, and the bounds of their habitation;
Acts 17:26
"According to a study published Jan. 10 in Nature by geneticists from 4 universities including Harvard, “Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants.” By recent they mean really recent on evolutionary timescales:
We estimate that approximately 73% of all protein-coding SNVs [single-nucleotide variants] and approximately 86% of SNVs predicted to be deleterious arose in the past 5,000–10,000 years. The average age of deleterious SNVs varied significantly across molecular pathways, and disease genes contained a significantly higher proportion of recently arisen deleterious SNVs than other genes.
The authors explained this in evolutionary terms as the result of “explosive population growth” and that “selection has not had sufficient time to purge them from the population.” They claimed Europeans had more variants “consistent with weaker purifying selection due to the Out-of-Africa dispersal.” The last paragraph assesses the impact of their findings:
More generally, the recent dramatic increase in human population size, resulting in a deluge of rare functionally important variation, has important implications for understanding and predicting current and future patterns of human disease and evolution. For example, the increased mutational capacity of recent human populations has led to a larger burden of Mendelian disorders, increased the allelic and genetic heterogeneity of traits, and may have created a new repository of recently arisen advantageous alleles that adaptive evolution will act upon in subsequent generations.
As for advantageous mutations, they provided NO examples. That’s merely an assumption, based on neo-Darwinian theory, that evolution would need beneficial mutations as raw material for “adaptive evolution” in the future. What they observed, by contrast, was a “larger burden of Mendelian disorders” afflicting mankind." CEH