Creation Moment 6/2/2022 - Made Male & Female

But from the beginning of the creation God made them male and female.

Mark 10:6

 

"All of the normal cells in a male have XY chromosomes; in a

normal female, XX chromosomes. The main exceptions involve enucleated cells, such as in the eye lens, and the blood cells. Two active X chromosomes results in an overdose of gene products, which is fatal for developing embryos and can lead to cancer in adult life.

 

Because two X chromosomes in one cell overproduce proteins, one X chromosome has to be turned off. This process, called X-inactivation, deals with the problem of dosage compensation. Consequently, early in embryonic development in females, one of the two X chromosomes is randomly and permanently inactivated.

This X-inactivation phenomenon is called lyonization after Mary Lyon who discovered the process. Lyonization in females will result in one X chromosome in each cell like is true in males.

 

A difference is, males have only one type of X chromosome, whereas females have two different X types, one type from the father and another type from the mother, but both will not be in the same cell. Because X-inactivation is random, in normal females the X chromosome inherited from the mother is active in some cells, and the X chromosome inherited from the father is active in other cells. For males, X-inactivation does not occur. Consequently, in males every cell that retains its chromosomes will have an X from the mother and a Y from the father.he cells that retain a nucleus other than egg cells.

 

Not all the chromosome genes are X-inactivated. Those located at the ends of each arm of the X and Y chromosome in areas called the pseudoautosomal regions are not inactivated. Furthermore, the same genes in the pseudoautosomal regions are present on both the X and Y sex chromosomes. As a result, men and women each have two functional copies of these genes which are essential for normal development.

One, called imprinting, is where certain genes are turned off in males and other genes are switched off in females. As a result, we have paternally imprinted genes and maternally imprinted genes.

 

Adding to this, a new control system has also been discovered.

Little is known about how X-chromosome inactivation affects the development of reproductive cells. In mammals, oocytes develop from germ cells, precursor cells that migrate from early embryonic tissue to the developing gonads. Germ cells then undergo meiosis, an important chromosomal rearrangement process, which is responsible for the genetic uniqueness of each individual germ cell. Germ cells mature and eventually turn into functional sperm or oocytes.

The new research found certain genes are turned both on and off at the proper time, and a correct X-chromosome inactivation and reactivation sequence indicates normal germ cell differentiation. Thus, depending on many factors, the research

revealed a carefully orchestrated act of X-chromosome ‘yoyo’. If one X chromosome [is] briefly inactivated and

then reactivated, it resulted in germ cells being four times more efficient for entering meiosis and transforming into egg cells compared to germ cells that have never turned their X chromosome ‘off and on’ again. In comparison, germ cells that failed to inactivate the X chromosome in the first place or reactivated it too rapidly showed abnormal gene expression and cell differentiation patterns.

Dr. Moritz Bauer, the co-first author of the study, explains one finding.

Our results also highlight how we need specific tools to study female cells. The vast majority of studies are performed using male cells, leading to a gender-gap in scientific knowledge. We therefore need to stop looking at female development through the lens of male cells, which will contribute to our understanding of sex-specific disease progressions.

What this means is that male cells and female cells are different even at the germ cell stage. 

These differences are now just being explored. This is one more observation which supports the fact that hormones and surgery cannot convert a male to a female, nor a female to a male. Sex operations and hormone therapy used in the so-called ‘transitioning’ from one sex to the other sex process is nothing more than cosmetic surgery. It is an attempt to change the appearance and does not make a male from a female, nor a female from a male. This corroborates the standard historical medical conclusion that gender dysphoria meant the need for a psychologist and not a surgeon."

 Jerry Bergman, PhD/CEH