Functional proteins form a miniscule fraction of this sequence space. This combinatorial problem, which has no analogue in the world of the machines that we build, must be successfully navigated to produce functional enzymes and molecular machines.
This is the reason that humans cannot design molecular machines or enzymes, or even antibodies to block viruses, which is far, far simpler than creating molecular machines or enzymes.
*Humans can create supercomputers, nuclear submarines, and jet airplanes but are nowhere close to being able to build protein-based molecular machines from scratch."
EN&V
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