"Mutations are word-processing errors in the cell’s instruction manual. Mutations systematically destroy genetic information—even as word processing errors destroy written information.
While there are some rare beneficial mutations (even as there are rare beneficial misspellings), bad mutations outnumber them—perhaps by a million to one.
So even allowing for beneficial mutations, the net effect of mutation is overwhelmingly deleterious. The more the mutations, the less the information.
This is fundamental to the mutation process."
Dr. John Sanford