The Nuremberg Rathaus displays the following architecture from Reformation thought on Daniel's Prophecies....
First, A lion & king Nebuchadnezzar of Babylon
Second, a bear & king Cyrus of Persia
Third, a 4 headed leopard & Alexander the Great of Greece
Fourth, a beast with 10 horns, which a "little horn" sticks out & Caesar of Rome
So even Reformers viewed the Little Horn coming up from Rome....NOT from Greece (the leopard) hence even they knew the Little Horn
was NOT an obscure Greek king named Antiochus IV Epiphanes.
I considered the horns, and, behold,
there came up among them another little horn,
Daniel 7:8