"In a study published in the journal Nature, researchers from the Center for Genomic Regulation (CRG) and the Wellcome Sanger Institute have discovered that mutations affect protein stability following remarkably simple rules.
Proteins are chains made up of twenty different types of smaller units
*A single mutation swaps one amino acid for another, changing the protein's shape.
*This can mark the difference between health and disease.
Many diseases, including cancer and neurodegenerative disorders, are caused by more than one mutation in a protein.
"Our discovery turns an old understanding on its head, showing that the endless possibilities of protein mutations boil down to straightforward rules. We don't need supercomputers to predict a protein's behavior—just good measurements and simple math will do," says Dr. Lehner."
"Our discovery turns an old understanding on its head, showing that the endless possibilities of protein mutations boil down to straightforward rules. We don't need supercomputers to predict a protein's behavior—just good measurements and simple math will do," says Dr. Lehner."
Phys.org