I will praise Thee; for I am fearfully and wonderfully made:
marvellous are Thy works;
Psalm 139:14
This is NO accident guided by the hand of Time + Chance
"Every cell in our body contains a complex machine called the ribosome responsible for making proteins. Proteins are the essential building blocks of life, and they perform various functions in our organs, tissues, and systems. Without proteins, we would not exist.Q: But how does the ribosome work?
Q: How does it assemble itself from dozens of different components?
Q: And what happens when it malfunctions?
The ribosome comprises ribosomal RNA and ribosomal proteins, following the instructions encoded in our genes to produce proteins. Ribosomes can be found in different cell parts, such as the cytosol, the mitochondria, or the bacteria.
The ribosome assembly is a complex and gradual process involving several stages.
One of the most interesting stages is the earliest one, which has not been described before. At this stage, a specific protein called GTPBP10 interacts with a long helix of RNA, which is a crucial part of the ribosome.
The mitochondrial ribosome is assembled from mitochondrial-encoded RNA and nuclear-encoded ribosomal proteins.
Assembly is coordinated in the mitochondrial matrix by biogenesis factors that transiently associate with the maturing particle.
Here, we present a structural snapshot of a large mitoribosomal subunit assembly intermediate containing 7 biogenesis factors including the GTPases GTPBP7 and GTPBP10.
Our structure illustrates how GTPBP10 aids the folding of the ribosomal RNA during the biogenesis process, how this process is related to bacterial ribosome biogenesis, and why mitochondria require two biogenesis factors in contrast to only one in bacteria.
“This helix contains the catalytic center of the ribosome, which is where proteins are made. This is why it is so important that the helix is folded and placed correctly,” says Kummer.
To achieve this, GTPBP10 grabs the helix and puts it in the right position for protein synthesis."
“This helix contains the catalytic center of the ribosome, which is where proteins are made. This is why it is so important that the helix is folded and placed correctly,” says Kummer.
To achieve this, GTPBP10 grabs the helix and puts it in the right position for protein synthesis."
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