And after that I looked, and, behold, the temple of the tabernacle of the testimony in heaven was opened:And the seven angels came out of the temple, having the seven plagues... Revelation 15:5,6
"In the fifteenth chapter of Revelation, verse 5, John speaks of the 
opening of the tabernacle of the testimony in heaven. This is the opening of the most holy place of the sanctuary,....The work there being concluded, as has been already explained,
---seven angels come out of the temple,
---having the seven plagues,
represented as seen golden vials full of the wrath of God.
They go forth to pour these out upon men, and the temple or sanctuary is filled with smoke, so that no man, or no being, as it might be translated, is able to enter therein, or carry forward a work of ministration there, till the seven plagues of the seven angels are fulfilled." Uriah Smith