I will praise thee; for I am fearfully and wonderfully made... Psalm 139:14
9-1-1 clamp -- a DNA damage "first responder" -- attaches itself to the site of a broken DNA strand to activate the DNA damage checkpoint.
The 9-1-1 clamp is shaped like a ring.
---To carry out its function, it
needs to surround the broken DNA at the junction between an exposed end
of one strand of a double-stranded piece of DNA abutting a
single-stranded one.
--- Consequently, the ring structure of the 9-1-1 clamp
must open to allow the single-stranded DNA to swing into the center of
the clamp and then reclose around it. This does not occur spontaneously
but is facilitated by another protein complex, called the clamp loader
complex.
It’s a complex process—and it’s just one small part of DNA repair, which is just one
small part of DNA. This couldn’t be the result of chance (after all,
DNA doesn’t have millions of years to wait for a proofreading and repair
system to evolve through trial and error!); it bears all the hallmarks
of an all-wise Creator who designed us to survive in a fallen world." AIG