Thursday, January 13, 2022

Creation Motion 1/14/2022 - Kinetochore "Machinery" Stuns Max Planck Team

 I will praise thee; for I am fearfully and wonderfully made
Psalm 139:14
 
"Beautiful. Flawless. 
The kinetochore (from the Greek “motion place”) binds the spindle fibers to the centromere of each chromosome, a spot at the center of a chromosome made for attachment to the spindle. 

Those who recall the stages of cell division in high school remember that the chromosome pairs all line up in the center of the cell. 
--At metaphase, something “lassos” each sister chromatid (individual member of the pair) at the centromere and exerts force to pull them apart into the daughter cells at anaphase.
 
--The kinetochore is right at the center of this action, binding to both the centromere and the microtubules in the spindle. 
It is therefore not only a machine able to contact each chromosome’s centromere; it is also a traffic cop. It will not let cell division proceed until it gives the green light.
 
What the Max Planck team actually saw was not a random, purposeless process on stage. They saw a beautiful, flawless machine that works perfectly almost all the time. Kinetochores are pulling chromosomes apart into daughter cells every day, in every eukaryotic organism, all over the world. 
Q: How many quadrillions of times has this occurred without an evolutionary upgrade?
 
 Musacchio’s team has been able to imitate the performance with homemade proteins. When they assemble their “Lego pieces” in a dish, they snap together like a kinetochore
 
Next, the team wants to see what their imitation machines do when given ATP for energy. Will they be able to pull on microtubules? Will they know when to play ‘red light, green light’?"
CEH