Thank you for making me so wonderfully complex!
Psalm 139:14
"If mitochondrial protein precursors are not transported into the mitochondria properly, they will accumulate on the outer surface of the mitochondria.
This leads to a mitochondrial-induced stress response by the cell whereby a number of cellular activities are affected.
As a consequence of improper transport by the transport channel, TOM (Translocon Outer Membrane), becomes clogged and proteins can no longer be transported into the mitochondria. This can lead to down-regulation of mitochondrial proteins which will compromise the synthesis of ATP.
The TOM itself is actually a complex of proteins.
The various members, numbered like Tom20 and Tom70, work together for the efficient transport of mitochondrial proteins through the outer membrane.
Each protein of the complex is encoded by its own gene, and the various genes are carefully regulated so that the correct number of components are ready for assembly of the TOM.
As the name implies, TOM is located in the outer membrane and forms the channel through which proteins traverse the outer membrane.
The TOM joins another protein complex, TIM (Translocon Inner Membrane), located in the inner membrane. TIM forms a channel through the inner membrane.
Together these two complexes of proteins form a complete channel through both membranes.
The TOM core complex is made up of Tom40, Tom22, and various small Tom proteins. This complex associates with Toms 20 and 70."
CMI
Psalm 139:14
This leads to a mitochondrial-induced stress response by the cell whereby a number of cellular activities are affected.
As a consequence of improper transport by the transport channel, TOM (Translocon Outer Membrane), becomes clogged and proteins can no longer be transported into the mitochondria. This can lead to down-regulation of mitochondrial proteins which will compromise the synthesis of ATP.
The TOM itself is actually a complex of proteins.
The various members, numbered like Tom20 and Tom70, work together for the efficient transport of mitochondrial proteins through the outer membrane.
Each protein of the complex is encoded by its own gene, and the various genes are carefully regulated so that the correct number of components are ready for assembly of the TOM.
As the name implies, TOM is located in the outer membrane and forms the channel through which proteins traverse the outer membrane.
The TOM joins another protein complex, TIM (Translocon Inner Membrane), located in the inner membrane. TIM forms a channel through the inner membrane.
Together these two complexes of proteins form a complete channel through both membranes.
The TOM core complex is made up of Tom40, Tom22, and various small Tom proteins. This complex associates with Toms 20 and 70."
CMI