Saturday, February 3, 2018

Creation Moment 2/4/2018 - SERPINE1

....and now, lest he put forth his hand, and take also of the tree of life, and eat, and live for ever:
Genesis 3:22
Was the secret to the Tree of Life a nutrient that kept the telomeres in their prime???

"A rare loss-of-function mutation in a gene called SERPINE1 identified among Old Order Amish in Indiana is associated with a longer lifespan, improved metabolism and a lower occurrence of diabetes, according to a Northwestern University-led study published this week.


Aging remains one of the most challenging biologic processes for scientists to unravel, due in part to the many interrelated molecular and cellular changes it brings.
One indicator of aging is the shortening of telomeres, caps at the end of strands of DNA that protect chromosomes of an individual.
Progressive shortening of telomeres leads to senescence, or biological aging.

Senescent cells and tissues exhibit a distinctive pattern of protein expression, including increased production of plasminogen activator inhibitor-1 (PAI-1).
To further examine the role of PAI-1 in human longevity, Dr. Sadiya Khan of the Northwestern University Feinberg School of Medicine and co-authors studied 177 members of the Berne Amish community, which included 43 carriers of a nonfunctional copy of the gene SERPINE1 (encodes PAI-1).

Carriers of this mutation lived an average of 10 years longer than other individuals in the community, according to the team.
Whats more, they had a 10% longer average white blood cell telomere length, after adjusting for age, sex, and familial relatedness compared with non-carriers." SciNews