The whole earth comes together to transgress the Law (breaking in
unity the 4th commandment) changing the Ordinance (transferring the solemnity of the 7th day Sabbath to the 1st day of the week by law-setting up a global counterfeit Sabbath) thereby breaking the Everlasting Covenant (by disconnecting True Righteousness by Faith- Justification/Grace+Sanctification/Obedience by claiming Grace while Disobeying the Law of God)
And the first went, and poured out his vial upon the earth;
and there fell a noisome and grievous sore upon the men which had the mark of the beast,
and upon them which worshipped his image.
Revelation 16:2