Wednesday, July 29, 2015

Creation Moment 7/30/2015 - M,N,R Genetics support Bible

"It comes as a surprise to most people to hear that there is abundant evidence that the entire human
race came from two people just a few thousand years ago (Adam and Eve), that there was a serious population crash (bottleneck) in the recent past (at the time of the Flood), and that there was a single dispersal of people across the world after that (the Tower of Babel). It surprises them even more to learn that much of this evidence comes from evolutionary scientists.

Y chromosome (which is only found in males and which is passed on directly from father to son) and in the mitochondrial DNA (a small loop of DNA that we nearly always inherit from our mothers only; males do not pass it on to their children). These two pieces of DNA record some startling facts about our  past.


 And the Lord God formed man out of the dust of the ground, and breathed into his nostrils the breath of life; and the man became a living being. Genesis 2:7

 And the Lord God caused a deep sleep to fall on Adam, and he slept; and he took one of his ribs, and closed up the flesh in its place. Then the rib which the Lord God had taken from the man he made into a woman, and He brought her to the man. Genesis 2:21–22

These simple statements have profound implications.
They put a limit on the amount of diversity we should find in people living today. The Bible clearly says the human race started out with two people only. But how different were these two people? There is an intriguing possibility that Eve was a clone of Adam. The science of cloning involves taking DNA from an organism and using it to manufacture an almost perfect copy of the original. Here, God is taking a piece of flesh, with cells, organelles, and, importantly, Adam’s DNA, and using it to manufacture a woman. Of course, she could not be a perfect clone, because she was a girl! But what if God had taken Adam’s genome and used it to manufacture Eve? All he would have had to do was to leave out Adam’s Y chromosome and double his X chromosome and, voilá, instant woman!

Your genome is like an encyclopedia (almost literally). And, like an encyclopedia, the genome is broken down into volumes, called chromosomes, but you have two copies of each volume (with the exception of the X and Y chromosomes; women have two Xs but men have one X and one Y). Imagine comparing two duplicate volumes side by side and finding that one word in a particular sentence is spelled differently in each volume (perhaps “color” vs “colour”). Can you see that if Eve was a clone of Adam, there would have been, at most, two possible variants at any point in the genome? If Eve was not a clone, however, there would have been, at most, four possible variants at any point in the genome (because each of the original chromosomes came in four copies). This still allows for a lot of diversity overall, but it restricts the variation at any one spot to 2, 3, or 4 original readings.

Does this fit the evidence? Absolutely! Most variable places in the genome come in two versions and these versions are spread out across the world. There are some highly variable places that seem to contradict this, but most of these are due to mutations that occurred in the different subpopulations after Babel.

There are indications, however, that Eve may not have been a clone. The ABO blood group is a textbook example of a gene with more than two versions. There are three main versions of the blood type gene (A, B, and O). However, many, but not all, people with type O blood carry something that looks very much like a mutant A (the mutation prevents the manufacturing of the type A trait on the outside of cells). So here is a gene with more than two versions, but one of the main versions is clearly a mutation. This is true for many other genes, although, as usual, there are exceptions. The important take home point is that essentially all of the genetic variation among people today could have been carried within two people, if you discount mutations that occurred after our dispersion across the globe. This is a surprise to many.

About 10 generations after Creation, a severe, short bottleneck occurred in the human population. From untold numbers of people, the entire world population was reduced to eight souls with only three reproducing couples.

 So Noah, with his sons, his wife, and his sons’ wives, went into the ark because of the waters of the flood. Genesis 7:7

 Now the sons of Noah who went out of the ark were Shem, Ham, and Japheth… These three were the sons of Noah, and from these the whole earth was populated. Genesis 9:18–19

We can draw many important deductions from these statements. For instance, based on Genesis 7 and 9, how many Y chromosomes were on the Ark? The answer: one. Yes, there were four men, but Noah gave his Y chromosome to each of his sons. Unless there was a mutation (entirely possible), each of the sons carried the exact same Y chromosome. We do not know how much mutation occurred prior to the flood. With the long life spans of the antediluvian patriarchs, it may be reasonable to assume little mutation had taken place, ...The amount of mutation may be a moot point, however, for, if it occurred, the Flood should have wiped out most traces of it (all of it in the case of the Y
chromosome).

How many mitochondrial DNA lineages were on the Ark? The answer: three. Yes, there were four women, but the Bible does not record Noah’s wife as having any children after the Flood (in this case, girl children). And notice the claim in Gen 9:19, “These three were the sons of Noah, and from these the whole earth was populated.”

The evidence from mitochondrial DNA fits our model just as neatly as the Y chromosome data. As it turns out, there are three main mitochondrial DNA lineages found across the world. The evolutionists have labeled these lines “M”, “N”, and “R”, so we’ll refer to them by the same names. They would not say these came off the Ark. It also turns out that M, N, and R differ by only a few mutations. This gives us some indication of the amount of mutation that occurred in the generations prior to the Flood.

Let’s assume ten female generations from Eve to the ladies on the Ark. M and N are separated by about 8 mutations (a small fraction of the 16,500 letters in the mitochondrial genome). R is only 1 mutation away from N. This is an indication of the mutational load that occurred before the Flood. Given the assumption that mutations occur at equal rates in all lines, about four mutations separate M and N each from Eve (maybe four mutations in each line in ten generations). But what about R? It is very similar to N. Were N and R sisters, or perhaps more closely related to each other than they were to M? We’ll never know, but it sure is fascinating to think about.

One more line of evidence crops up in the amount of genetic diversity that has been found within people worldwide. Essentially, much less has been found than most (i.e., evolutionists!) predicted. However, the reason for this lack of diversity is..... First, the human race started out with only two people. Second, the human race is not that old and has not accumulated a lot of mutations, despite the high mutation rate. Third, there actually was a bottleneck event, Noah’s Flood!

There is one more verse in this section that we need to discuss:

 These were the families of the sons of Noah, according to their generations, in their nations; and from these the nations were divided on the earth after the flood. Genesis 10:32


At Babel, God did not separate the nations according to language. He used language to separate them according to paternal (male) ancestry! This has monumental significance and is the key to understanding human genetic
history. Paternal sorting would lead to specific Y chromosome lineages in different geographical locations. Since males and females from the three main families should have been freely intermixing prior to this, it also leads to a mixing of the mitochondrial lines. It is as if God put all the people into a giant spreadsheet and hit a button called “Sort According to Father.” He then took that list and used it to divide up and separate the nations.

We already saw that Y chromosomes have little variation among them. We now add the fact that this little bit of variation is almost always geographically specific. That is, after the nations were separated according to Y chromosome, mutations occurred in the various lines. Since the lines were sent to specific geographical areas, the mutations are geographically specific. The current distribution of Y chromosome lines is a tremendous confirmation of the biblical model.

Mitochondrial DNA (mtDNA) adds another confirmation. We have already learned that there are three main lineages of mtDNA. We now add the fact that these three lineages are more or less randomly distributed across the world. Also, the various mutations within each of the three main families of mtDNA are geographically specific as well. In other words, as the three mixed mitochondrial lines were carried along with the Y chromosome dispersal, each line in each area began to pick up new mutations, just like we would predict." CMI/Dr. Robert Carter