Sunday, November 16, 2014

Creation Moment 11/17/2014 - The 3 arguments of Avise: #2

"In the May 11, 2010 issue of the Proceedings of the National Academy of Sciences (PNAS), John
Avise authored a paper titled “Footprints of Nonsentient Design Inside the Human Genome” (Avise, 2010). In this article, Avise highlighted several alleged evidences from the human genome which, according to him, prove it could not have been created by intelligent design, but rather must be a product of natural selection over countless years of time. The author calls his evidence an “argument from imperfection.” The thesis for his argument in favor of evolution is that the human genome, while undeniably complex, is riddled with errors and imperfections. Avise contends that the simple presence of these alleged fallibilities argues against an omnipotent Creator and, instead, is evidence for a nonsentient process (natural selection). This article addresses each of the major arguments posed by Avise.




The second argument brought forth by Avise to contend with creationism is one that, traditionally, creationists have championed over the years: biological complexity. Stemming in part from Michael Behe’s Darwin’s Black Box (1996), the immense nature of biological complexity has been used widely to dispute evolution. Here the author asserts:

[G]ratuitous or unnecessary, biological complexity—as opposed to an economy of design—would seem to be the antithesis of thoughtful organic engineering. Yet, by objective scientific evidence, gratuitous and often-dysfunctional complexities (both in molecular structure and molecular operations) are so nearly ubiquitous as to warrant the status of hallmarks of the human genome (Avise, p. 8972).
Two major areas of complexity are addressed by Avise as being “gratuitous”: gene splicing and gene regulation. 
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Gene splicing still puzzles scientists today, more than 30 years after its initial discovery. Most eukaryote genes (DNA sequences that code for proteins) exist in their respective genomes as fragmented DNA sequences separated into these pieces by other non-coding DNA. The intervening non-coding sequences are known as introns, while the fragments of functional coding DNA are known as exons. When genes are transcribed into mRNA prior to protein production, the introns must be cut away and the fragmented exons spliced together to generate a functional mRNA molecule ready to be read into protein.
As described in this article, a vast amount of genome space, cellular energy, time, and other resources are devoted to this splicing process. The author makes the claim that this rigmarole (to get a functional mRNA) is overly complex and thus evidence against a Creator. The problem with his logic is twofold.

First, there are known advantages attained by the human cell because we splice our mRNAs. The human genome encodes an estimated 24,000 different genes. But, through a process known as alternative splicing, our cells have the capacity to make much greater numbers of distinct proteins. Most genes whose exons are spliced may be spliced together in different ways using different combinations of exons. This allows for one gene in the human genome actually to manufacture multiple, distinct protein products, extending what we refer to as the proteome into a size much larger than that of the genome. Furthermore, alternative splicing allows a single uniform human genome to encode countless different protein combinations, making our differing cell types unique.

The second problem with this logic is that if we assume gene splicing is gratuitously complex, then why would natural selection have favored its inception and maintenance over millions to billions of years? Bacteria do not splice their genes and even lack the machinery for the splicing processes. So, if splicing arose by evolutionary mechanisms and is found in higher organisms, then according to evolutionary theory, it must present some fitness advantage. Avise argues that splicing is too complex and that the fitness costs outweigh the benefits. This simply does not conform to the paradigm of natural selection. The truth is that splicing is an advantage to eukaryotic species, including humans, and is one of many reasons why we are more complex than bacteria. Therefore, this advantageous process is not a mistake of creation, but rather a highlight of creation." ApologeticsPressI will praise thee; for I am fearfully and wonderfully made:
Psalm 139:14