Alexander crushed the Medo-Persian Empire-- And he came to the ram that had two horns, which I had seen standing before the river, and ran unto him in the fury of his power. And I saw him come close unto the ram, and he was moved with choler against him, and smote the ram, and brake his two horns: and there was no power in the ram to stand before him, but he cast him down to the ground, and stamped upon him: and there was none that could deliver the ram out of his hand. Daniel 8:6,7
Upon the death of Alexander his empire was divided between his four generals--Now that being broken, whereas four stood up for it, four kingdoms shall stand up out of the nation, but not in his power. Daniel 8:22